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The remaining 10-15% are due to unequal segregation of a parental balanced translocation where the 5p monosomy is often accompanied by a trisomic portion of the genome.

These individuals may have more severe disease than those with isolated monosomy of 5p.

While levels of proficiency can range from a few words to short sentences, it is often recommended by medical professionals for the child to undergo some sort of speech therapy/aid with the help of a professional.

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Fewer than 10% of cases have other rare cytogenetic aberrations (e.g., interstitial deletions, mosaicisms, rings and de novo translocations).

The deleted chromosome 5 is paternal in origin in about 80% of de novo cases.

Affected children are typically diagnosed by a doctor or nurse at birth.

Genetic counseling and genetic testing may be offered to families with individuals who have cri du chat syndrome.

In males, testes are often small, but spermatogenesis is thought to be normal.

Cri du chat syndrome is due to a partial deletion of the short arm of chromosome number 5, also called "5p monosomy" or "partial monosomy." Approximately 90% of cases result from a sporadic, or randomly occurring, de novo deletion.

Affected females reach puberty, develop secondary sex characteristics, and menstruate at the usual time.

The genital tract is usually normal in females except for a report of a bicornuate uterus.

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